Does Weed Have Negative Interactions With Your Legal Pharmaceuticals?

More people have access to medical, nutritional, and adult-use cannabis than ever before. Yet, many consumers feel uncomfortable broaching the subject with medical professionals. This means that many consumers may be unaware that the herb might be negatively interacting with their pharmaceutical medications. Cannabis can have both positive and negative effects on prescription drugs.

How you respond to cannabis is highly individual. Some people may find that the herb helps them better manage side effects related to certain medical treatments. Others may find that cannabis allows them to reduce their dosages of certain pharmaceuticals.

However, it’s also entirely possible to have severe and harmful drug interactions with adding cannabis to your pharmaceutical cocktail. Here’s the scoop on how cannabis may affect some of the most common prescription medications:

Does Marijuana have negative interactions with Your Legal pharmaceuticals?

Your physician needs to know what you’re taking, and what you’re not taking. Unlike many prescription drugs, cannabis is non-toxic and has a high margin of safety when compared to other commonly consumed substances like alcohol, tobacco, and caffeine. In fact, according to the U.S. Drug Enforcement Administration (DEA) and the Centers for Disease Control (CDC), there have been zero reported deaths from cannabis overdose.

Yet, just because cannabis is safe on its own does not mean that it is good to mix with all medications. Cannabis is a powerful herb that can have profound effects on the body. This includes the ability to either counteract or enhance the effects of certain pharmaceutical medications. If you are considering adding in cannabis to any sort of treatment routine, it’s wise to ask your doctor about possible drug interactions. While more research is needed, there are a few types of prescription drugs that may have increased side effects when combined with cannabis.

Blood pressure medications

Other name for Blod presure meds is beta blockers are drugs used to lower blood pressure by blocking the effects of adrenaline, the hormone responsible for the fight or flight response. Taking beta blockers reduces your heart rate and prevents cardiac stress. Cannabis, however, may have contrasting or amplifying effects on beta blockers. The herb can cause blood pressure to fluctuate while simultaneously causing the heart to beat faster in some people.

In novice consumers, blood pressure may increase slightly. Regular consumers can become tolerant to these effects and may even experience reduced blood pressure and heart rate. However, the potential increase in heart rate is thought to increase your risk of having a heart attack. Especially in those with a predisposition for heart problems or who have a pre-existing condition.

The complex effects that both of these treatments have on heart rate may make combining cannabis and blood pressure medication might be a bad idea. Some of the side effects to look out for include dizziness, feeling faint, irregular heartbeat, fatigue, and nausea. If you notice peculiar or prolonged heart complications, contact a medical professional.

Presciription Sedatives

Those taking sedative medications such as sleeping medications, anti-anxiety medications (benzodiazepines), mood stabilizers, antipsychotic medications, and anticonvulsant medications will need to be cautious with cannabis. Cannabis can amplify the sedative qualities of tranquilizing drugs, producing an additive effect.

Combining cannabis with tranquilizers like sleeping pills or anxiety medications like Ativan or Xanax may cause some consumers to feel overly sedated to the point that it becomes unpleasant. Some symptoms to watch for include slow and impaired speech, slowed movement, dizziness, fatigue, and lethargy. When used in combination with a sedative medication, cannabis should be monitored closely.

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Some people taking antidepressant medications may experience negative effects when mixing cannabis with pharmaceuticals. Both cannabis and certain common types of antidepressants (such as Prozac, Zoloft, Cymbalta, etc.) have an effect on the neurotransmitter serotonin.

Animal research suggests that cannabis can cause spikes or drops in serotonin depending on the dose. On their own, antidepressant medications can sometimes cause a condition called serotonin syndrome (SS). This happens when levels of the normally calming neurotransmitter become too high.

In extreme cases, SS can be life threatening. The condition can cause agitation, anxiety, headache, confusion, mania, shivering, nausea, sweating, diarrhea, tremors, and more. There is little high-quality evidence that cannabis contributes to SS. However since the herb has an effect on serotonin, it is important to be mindful when mixing the substances. Chances are if you’re having a bad experience, something is awry.

Some cannabis compounds may also change how the body breaks down antidepressants, which means that the herb can enhance their effect. This potentially puts patients at a greater risk of negative serotonin side effects.


When combining cannabis with opioid pain medications, you may need to lower your dose of the prescription drug. Cannabis can interact with the opioid system in the body, which contributes to the herb’s pain-relieving effects.

While recent medical literature suggests that combining cannabis with opioid treatments may improve pain control and reduce the dosage of opioid painkillers needed for therapeutic effect, combining the two types of medications is something that should be monitored. Those taking drugs that include buprenorphine, a particular type of opioid pain medication, may need to be especially careful. Both substances can have depressant effects on the central nervous system and may hinder the respiratory system in extreme cases. The interactions with cannabis and other opiates like morphine are currently thought to be less severe.

Some of the negative side effects may include increased sedation, dizziness, confusion, and impaired motor coordination. In extreme and rare cases difficulty breathing and respiratory problems may occur.

Blood thinners

Cannabis may amplify the effects of blood thinning medications like Warfarin. This means that you might bleed a little easier. In some cases, lowering the dose of these medications may be valuable if you want to continue with cannabis consumption. Though, it’s important to always work closely with a medical professional before adjusting dosages.

Additional research suggests that CBD may be a useful add-on treatment in psychotic disorders.

More research still suggests that cannabis compounds can improve insulin sensitivity, decrease inflammation, and improve glucose metabolism in patients with diabetes. This is not to mention the wealth of recent research that suggests that CBD effectively reduces seizures in some forms of intractable epilepsy, like the small study mentioned above.

Yet, mixing cannabis with pharmaceutical drugs is tricky business. Every patient will react differently depending on what types of chemical cocktails exist in their bodies at a given period of time. It’s important to listen closely to your body and communicate clearly with medical professionals about any new side effects or concerns when mixing the herbal medicine with pharmaceuticals.

Always consult a doctor when making changes to your treatment plan or self-treating, i think is the best advice.

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