Both Cannabis and Psilocybin Mushrooms are naturally occurring organisms. They live and grow in nature. Each plant or mushroom produces its own cocktail of chemical compounds — cannabinoids, terpenes, psilocybin derivatives, etc..
Cannabis and psilocybin mushrooms both contain multiple active ingredients. Cannabis contains hundreds of cannabinoids and terpenes. Psilocybin mushrooms contain a cocktail of active molecules, including at least eight different psilocybin derivatives like baeocystin, norbaeocystin, serotonin, and aeruginascin.
The cannabis industry has recently learned that many of the lesser known active ingredients (e.g., CBD, CBC, CBG, THCv, etc.) in cannabis can be more valuable than THC, which was once believed to be the only molecule worth studying.
Psilocybin is still universally described as “the” (sole) active ingredient in magic mushrooms. (Notably, psilocybin is not actually the active ingredient. Rather psilocybin is a prodrug of psilocin, which provides the psychedelic effects.) Although the scientific literature unquestionably confirms the presence and activity of other psilocybin derivatives, those molecules have never been studied.
Both cannabis and psilocybin mushrooms work via an “Entourage Effect.” In other words, the multiple active ingredients contained in each organism synergistically produce the effect experienced by the user.
Cannabis and magic mushrooms are all-natural drugs that produce uplifting, euphoric highs. These two substances can be safely consumed together under the right conditions. Many people find that the psychoactive effects produced by these drugs complement one another, leading to a more pleasant and fulfilling experience.
THE CANNABIS HIGH
The cannabis plant contains at least 113 different cannabinoids including THC and CBD. Tetrahydrocannabinol (THC) is the active cannabinoid responsible for the plant’s psychoactive properties. Conversely, cannabidiol (CBD) has been known to dampen some of the effects of THC, making it less intense.
Cannabis is considered to be a “downer” because of its calming, sedative effects. The high it produces can be both euphoric and sedating at the same time. The intensity of these effects will depend largely on the cannabinoid ratio found in the plant being consumed. A higher CBD count, and lower THC count, will result in a less psychoactive and sedative high, for instance. Cannabis’ sedative effects promote relaxation, oftentimes accompanied by heightened sensory perception and a warped sense of time.
Marijuana can have some negative effects on the brain’s short-term ability to function. It is known to negatively affect things like motor function, coordination, and reflexes. It also tends to cause dry mouth and dry eyes, especially in regular users. Moreover, those coming down from a cannabis high typically feel tired, drained, and drowsy. It is important to be mindful of these adverse effects when consuming cannabis.
THE MUSHROOM HIGH
Magic mushrooms induce a euphoric and hallucinogenic high. The primary psychoactive compounds in mushrooms are psilocybin and psilocin. Together, these compounds are responsible for the intense, mind-altering effects that characterise the high.
When consumed, psilocybin is quickly converted to psilocin through metabolisation. Psilocin then acts on serotonin receptors in the brain, partially activating several of them. Psilocin also indirectly increases the concentration of dopamine in the basal ganglia. It is these reactions that are primarily responsible for the strong euphoric sensations experienced when ingesting magic mushrooms.
Psilocybin mushrooms are considered to be “uppers” because of the energising mind and body buzz that they produce. This hallucinogenic high is usually accompanied by giddiness, joy, a distorted perception of time, closed-eye visuals, and out-of-body sensations.
It is believed that magic mushrooms work by rewiring the brain’s information processing pathways. This rewiring can oftentimes lead to intensely strong emotions being experienced during the trip. Sometimes, exceptionally intense trips are compared to profound religious experiences. The average psilocybin trip can last anywhere from 3–6 hours, depending on dosage. However, because of the intensity of the effects, it can feel much, much longer.
There are many possible adverse reactions that one can have during a magic mushroom trip. About a third of mushroom users report experiencing some form of anxiety or paranoia during their high. More acute anxious reactions can sometimes result in nausea or full-blown panic attacks. Other psychological side effects can take the form of depression, lethargy, and disorientation. The physical side effects of psilocybin mushrooms can include restlessness, dilated pupils, increased body temperature, fever, sweats, and chills.
THE EFFECTS OF MIXING BOTH
When combined, cannabis and mushrooms have a synergistic effect. Many people report that the inclusion of cannabis both increases the intensity of their mushroom trip, and keeps them relaxed throughout it.
Mixing magic mushrooms and cannabis can produce an intensely psychedelic high characterised by abstract and thought-provoking visuals and sensations. Marijuana’s calming effects can dull the come-up of a mushroom trip, keeping you more relaxed during the early stages of the high. Moreover, some believe that consuming cannabis can lead to a more intense peak, and can even keep you more relaxed during the come-down stage.
Both mushrooms and cannabis can have an indirect effect on dopamine, a neurotransmitter known as a “feel-good” or “reward” chemical. This effect is capable of producing feelings of motivation and ambition throughout a trip. However, it is also responsible for leading the brain into repetitive or indecisive thought patterns. By consuming both of these substances at the same time, the intensity of these effects will be significantly increased.
Regular users of mushrooms or cannabis may find mixing them to be a very enjoyable experience. Being comfortable with these two substances is crucial to allowing them to facilitate and enhance your exploration of the mind. If you are not comfortable with consuming either, then ingesting them both at the same time is not recommended.
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