As CBD and THC enjoy the majority of the cannabis cannabinoid spotlight, a new natural marijuana molecule has been discovered by the name of THCP.
A study published by Nature.com has revealed the discovery of two previously unknown cannabinoids, now named THCP and CBDP. In tests on mice, researchers found that THCP demonstrated “an affinity for CB1 receptor more than thirty-fold higher compared to the one reported for THC,” making it much stronger than THC.
“THCP is endowed of an even higher binding affinity for CB1 receptor and a greater cannabimimetic activity than THC itself.” – “A novel phytocannabinoid isolated from Cannabis sativa L. with an in vivo cannabimimetic activity higher than Δ9-tetrahydrocannabinol: Δ9-Tetrahydrocannabiphorol,” Nature Research, 2019
The other compound – CBDP – reportedly doesn’t bind well to CB1 or CB2 receptors which doesn’t make the cannabinoid a priority for further research; however, the researchers said that THCP “should be included in the list of the main phytocannabinoids to be determined for a correct evaluation of the pharmacological effect of the cannabis extracts administered to patients.”
Considering the many benefits that cannabis already provides to consumers, like the treatment of epilepsy and glaucoma, it is clear that there is substantial nutrients to be had. However, its legal status has forced cannabis to remain an illicit drug, despite the many cannabinoids that can help the public. In fact, the variations in the molecules have allowed researchers to discover a total of about 150 different known phytocannabinoids in the process. Like THCV, THCP likely has different pharmacokinetics and binding properties than THC alone.
Due to the findings of the study, the researchers suggested that “THCP is endowed of an even higher binding affinity for CB1 receptor and a greater cannabimimetic activity than THC itself.” Basically, they stated that THCP is more powerful than THC in its effects of the body, which has never been found naturally in the cannabis plant before now. However, with mass spectrometry and analytical techniques, it was possible to discover new compounds that have not previously seen much attention.
The discovery of THCP might also help explain the puzzling pharmacological properties of certain cannabis strains that previously could not be attributed to the presence of THC alone, researchers said.
“In our opinion, this compound should be included in the list of the main phytocannabinoids to be determined for a correct evaluation of the pharmacological effect of the cannabis extracts administered to patients.”
According to the study, new work will continue to test and see how THCP cannabinoid acts as an antioxidant, anti-inflammatory and anti-epileptic activity, which are the health benefits most associated with CBD (cannabidiol).
If this substance proves to be one of the rising stars of the cannabis industry, regulators would need to be clearer over the legal status of any type of cannabis. Additional research will be needed to make this compound into a substance that could actually be purchased, but it is clear that additional options may soon be available to consumers with more severe symptoms to treat.
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